Novel Cytokine Inhibitors (Progress in Inflammation Research .) (2000. viii, 270 S. Illustr. 235 mm)

§16§Cytokines have become established as key mediators of the signs and §symptoms of inflammatory diseases such as arthritis, dermatitis, asthma §and multiple sclerosis. Furthermore, they are involved in the cascade of §events leading to cardiovascular shock and are major regulators of the §function of immune cells. §This book reviews recent advances in the development of new §anti-inflammatory drugs. It addresses different therapeutic intervention §possibilities for new drugs, such as the cellular source of cytokines, §specific receptors which induce cytokine synthesis, intracellular §regulators of cytokine gene induction and expression, secretion and §activation of cytokines, cytokine receptors and signalling pathways from §these receptors. Accordingly, experts were drawn from different §backgrounds including academic research institutes, the pharmaceutical §industry and clinical pharmacology. In each area, the opportunities for §drug development are highlighted and, where possible, §16§ clinical data is §reviewed. §04§Contents. List of Contributors. Brian Henderson and Gerry Higgs: Targets §for modulating cytokine responses in inflammatory and infectious §diseases. Mary Lee MacKichan and Anthony L. DeFranco: Cell signalling §and cytokine induction by lipopolysaccharide. Rodger A. Allen and §Stephen E. Rapecki: Regulation of cytokine production by inhibitors of §cell signalling. Stanley T. Crooke: Oligonucleotide-based drugs in the §control of cytokine synthesis. Peter I. Croucher, Ingunn Holen and §Philip G. Hargreaves: Inhibiting cytokine-processing enzymes. Amanda §Suitters and Roly Foulkes: Cytokine-neutralizing therapeutic antibodies. §Ravinder N. Maini: The debut of anti-TNF therapy of rheumatoid arthritis §in the clinic. Anthony Meager: Blockade of cytokine activity by soluble §cytokine receptors. Michael F. Smith Jr.: Interleukin-1 receptor §antagonist. Raymond J. Owens and Simon Lumb: Therapeutic regulation of §cytokine signalling by inhibitors of p38 mitogen-activated protein §kinase. §04§Christian Bogdan, Yoram Vodovotz and John Letterio: TGF-ß and §IL-10: inhibitory cytokines regulating immunity and the response to §infection. Brian Henderson: Therapeutic control of cytokines: lessons §from microorganisms. Index