Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated system (Cas) is a system that provides immunity to the most of prokaryotic organisms against viral attacks and other foreign bodies. Crispr systems consist of a scissor-like protein called Cas9 and a genetic GPS guide "The guide RNA". However, researchers reoriented and repurposed that primordial immune system to precisely manipulate genomes in most organisms by introducing DNA double- strand breaks at specific genome locations to introduce specific DNA modifications.More applications of CRISPR have arisen since its discovery, from disabling parasites to correcting mutations and improving the crop yields.This research is conducted to be as a guide to the CRISPR technology, from the history of discovering it to the latest breakthroughs.It is hoped this study would provide a general-based view for this life changing technology and to inspire scientists to go further with CRISPR in the sake of a better life. BENADJEL, Oumayma Dr Oumayma BENADJEL, Veterinary Doctor, MVSc at the National High School of Veterinary Medicine, Algiers, Algeria.
