This book gathers high-quality research papers presented at the 6th International Conference on Frontiers in Computing and Systems (COMSYS 2025) held at Faculty of Mathematics and Information Science, Warsaw University of Technology, Warsaw, Poland, during 25 27 September 2025. The book is divided into four volumes, and it covers research in cyber-physical systems for real-life applications pertaining to AI, machine learning and data science; devices, circuits, and systems; computational biology, biomedical informatics, and network medicine; communication networks, cloud computing, and IoT; image, video, and signal processing; and security and privacy.
