Evidence has been piling up that small RNAs are able to control gene expression by directed control of epigenetic modifications at particular genomic loci. Biological scientists from the anglophone world, France, and Japan review research findings into the RNA regulation of gene expression, an acknowledgment and understanding of which could alter the current paradigm in molecular biology significantly. Their topics include the epigenetic regulation of gene expression, the role of non-coding RNAs in controlling mammalian RNA polymerase II transcription, and therapeutic potential. Annotation 2008 Book News, Inc., Portland, OR (booknews.com)
