Contributors from a wide range of medical specialties explain diagnostic and prognostic approaches that employ measuring nucleic acids in clinical situations. They focus on cancer and infectious diseases, and devote considerable attention to the process of translating a preclinical test to the bedside. Among the topics are transcriptome-based biomarkers: a road map exemplified for peripheral blood-based biomarker discovery, development, and clinical use; genetic and epigenetic biomarkers of colorectal cancer; viral diagnostics and methodologies based on real-time quantitative polymerase chain reactions (qPCR); ancient DNA and fingerprints of disease: retrieving human pathogen genome sequences from archaeological remains using qPCR; and clinical applications and current technologies for point-of-care nucleic acid testing. Distributed in the US by ISBS. Annotation 2014 Ringgold, Inc., Portland, OR (protoview.com)
