{"product_id":"9783110258769","title":"Extracellular Matrix: Pathobiology and Signaling (2012. L, 888 S. 160 col. ill., 60 b\/w tbl. 240 mm)","description":"\u003cp\u003eOver the last decades cell biology and biological chemistry have increasingly turned their attention to the space between cells and revealed an elaborate network of macromolecules essential for structural support, cell adhesion and signaling. This comprehensive handbook of the extracellular matrix will give an overview of the current state of knowledge of matrix components (structure and function), their role in heath and disease (matrix pathobiology) and new aspects related to pharmacological targeting.\nIt will provide an introduction to the extracellular matrix and detailed sections and chapters on:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eImportance of extracellular matrix in health and disease \u003c\/li\u003e\n\u003cli\u003eMatrix proteoglycans (aggrecan, versican, perlecan, SLRPs, syndecans, glypicans, serglycin) \u003c\/li\u003e\n\u003cli\u003eMatrix proteinases (remodeling, would healing, regulatory roles in health and disease, metalloproteinases, cystein proteases, plasmin and plasminogen activator system) \u003c\/li\u003e\n\u003cli\u003eGlycobiology (hyaluronan and sulfated glycosaminoglycans in cancer, inflammation and metabolic control) \u003c\/li\u003e\n\u003cli\u003eCollagens (supramolecular assembly, proteins binding collagen, scaffolds, bacterial and mutated collagens, procollagen proteinases) \u003c\/li\u003e\n\u003cli\u003eCell surface receptors (integrins, syndecans, mechanical strain and TGFb, CD44 and DDR). \u003c\/li\u003e\n\u003cli\u003eBiotechnological and pharmacological outlook (matrix regulation by growth factors, hyaluronidases, pathobiology, disease targeting, delivery systems, EMT and proteomics).\u003c\/li\u003e\n\u003c\/ul\u003e \u003cp\u003e\"The book Extracellular Matrix: Pathobiology and Signaling provides a comprehensive and up to date collection of very relevant topics for understanding the various facets of extracellular matrix and its interactions with cells in normal tissue as well as in disease. It represents the current front-line and will serve as a reference for extracellular matrix and posttranslational modifications.\"\u003c\/p\u003e \u003cp\u003eDick Heinegård, Department of Clinical Sciences Lund, Section Rheumatology, Lund University, Sweden\n\n\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eNikos K. Karamanos,\u003c\/strong\u003e Biochem. Lab, Department of Chemistry, University of Patras, Greece.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eSection-Editors: Donald Gullberg, \u003c\/strong\u003eDepartment of Biomedicine, University of Bergen, Norway; \u003cstrong\u003eParaskevi Heldin, \u003c\/strong\u003eLudwig Institute for Cancer Research, Uppsala University, Sweden; \u003cstrong\u003eLiliana Schaefer, \u003c\/strong\u003eInstitute of General Pharmacology and Toxicology, Goethe-University, Frankfurt, Germany; \u003cstrong\u003eRuggero Tenni, \u003c\/strong\u003eDepartment of Biochemistry, Pavia University, Italy;\u003cstrong\u003e Achilleas Theocharis, \u003c\/strong\u003eDepartment of Chemistry, University of Patras, Greece; \u003cstrong\u003eJan-Olof Winberg, \u003c\/strong\u003eDepartment of Medical Biology, University of Tromsø, Norway.\u003c\/p\u003e","brand":"De Gruyter","offers":[{"title":"Default Title","offer_id":52365061226807,"sku":"00000_00000_00000_00000","price":2492.28,"currency_code":"MYR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0962\/3548\/7543\/files\/9783110258769-1.jpg?v=1783264305","url":"https:\/\/kinokuniya.com.my\/products\/9783110258769","provider":"Books Kinokuniya Malaysia","version":"1.0","type":"link"}